Therapeutic use of recombinant methionyl human leptin
نویسندگان
چکیده
منابع مشابه
Therapeutic use of recombinant methionyl human leptin.
Recombinant methionyl human leptin (r-metHuLeptin) was first used as a replacement therapy in patients bearing inactivating mutations in the leptin gene. In this indication, it was shown since 1999 to be very efficient in inducing a dramatic weight loss in rare children and adults with severe obesity due to the lack of leptin. These first clinical trials clearly showed that r-metHuLeptin acted ...
متن کاملRecombinant DNA expression products for human therapeutic use
Recombinant DNA (rDNA) technology has made a revolutionary impact in the area of human healthcare by enabling mass production of safe, pure and effective rDNA expression products. Currently, several categories of rDNA products, viz. hormones of therapeutic interest, haemopoietic growth factors, blood coagulation products, thrombolytic agents, anticoagulants, interferons, interleukins and therap...
متن کاملTherapeutic Use of Native and Recombinant Enteroviruses.
Research on human enteroviruses has resulted in the identification of more than 100 enterovirus types, which use more than 10 protein receptors and/or attachment factors required in cell binding and initiation of the replication cycle. Many of these "viral" receptors are overexpressed in cancer cells. Receptor binding and the ability to replicate in specific target cells define the tropism and ...
متن کاملProduction of polyclonal antibodies directed to recombinant methionyl bovine somatotropin.
The administration of recombinant methionyl bovine somatotropin (rMbST) to dairy cows to increase milk yield remains a common practice in many countries including the USA, Brazil, Mexico, South Africa and Korea, whereas it has been forbidden within the European Union (EU) since 1999. A rapid screening immunoanalytical method capable of the unequivocal determination of rMbST in milk would be hig...
متن کاملUtility of P19 Gene-Silencing Suppressor for High Level Expression of Recombinant Human Therapeutic Proteins in Plant Cells
Background: The potential of plants, as a safe and eukaryotic system, is considered in the production of recombinant therapeutic human protein today; but the expression level of heterologous proteins is limited by the post-transcriptional gene silencing (PTGS) response in this new technology. The use of viral suppressors of gene silencing can prevent PTGS and improve transient expression level ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimie
سال: 2012
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2012.03.013